Tejinder Kataria
Medanta Cancer Center, India
Title: Can PETCT parameters predict survival for recurrent head and neck cancer with cyberknife stereotactic body radio therapy (SBRT)?
Biography
Biography: Tejinder Kataria
Abstract
There are established guidelines for baseline diagnosis and post treatment surveillance among head and neck cancer (HNC) patients with PET-CT parameters like standardized uptake value (SUV), metabolic tumor volume (MTV) and Total lesion glycolysis (TLG). The same remains controversial and experimental among post irradiation (RT) recurrence especially with Stereotactic Body Radiotherapy (SBRT). We analyzed the PET-CT parameters with the intent to co-relate the response and survival among post RT recurrent HNC (rHNC) undergoing Cyberknife SBRT. Materials & Methods: Thirteen (10 male and 3 female) HNC patients with post RT recurrence undergoing Cyberknife- SBRT were analyzed. Six patients had loco-regional recurrences, five had nodal while one each had distant nodal and 2nd primary HNC. All patients had post treatment follow up PET scan and in case of residual disease being a suspicion, had biopsy/FNAC to prove a recurrence. All patients received Cyberknife- SBRT alone with median dose per fraction 6 Gy (5-12 Gy) in 5 fractions (3-7 fractions). Pre Cyberknife median SUVmax, MTV and TLG were calculated using custom-designed software. Post Cyberknife at 10-12 weeks the values were recorded again. At the time of analysis the last follow up status, objective response and median values of PET parameters were used as cutoffs while assessing their prognostic potential through Chi-sqaure test, Cox regression analyses, ROC analysis and Pearson's correlation respectively.