Saeed Shanehsazzadeh
University of Mons, Belgium
Title: Biodistribution assessment of 68Gallium radiolabeled PEGcoated superparamagnetic iron oxide nanoparticles in normal mice
Biography
Biography: Saeed Shanehsazzadeh
Abstract
Objectives: The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Materials and methods: Three mice were sacrificed at specific time intervals (5, 15, 30 and 60 and 120 minutes post-injection) and the percentage of injected dose per gram of each organ was calculated by counting of each organ of mice. Results: The biodistribution data revealed high amount uptake by liver and spleen (51.70 and 16.92 %ID/g by liver and spleen at 30 minutes, respectively and these values were 60.62 and 12.65 %ID/g at 120 minutes post injection). The clearance of other organs was fast. Conclusion: These results suggest that 68Gallium radiolabeled PEGylated superparamagnetic iron oxide nanoparticles (68Ga-PEG-SPIONS) has susceptibility for applying in Positron emission tomography- Magnetic resonance Imaging (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.